An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2.
ChEBI ID: 77103
| Member | Definition | Class |
|---|---|---|
| brequinar | A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. | brequinar |
| brequinar sodium | An organic sodium salt of brequinar. | brequinar sodium |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 16 (7.05) | 18.7374 |
| 1990's | 129 (56.83) | 18.2507 |
| 2000's | 16 (7.05) | 29.6817 |
| 2010's | 30 (13.22) | 24.3611 |
| 2020's | 36 (15.86) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 15 (6.47%) | 5.53% |
| Reviews | 25 (10.78%) | 6.00% |
| Case Studies | 1 (0.43%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 191 (82.33%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 0.0018 | 1 | 1 |
| Dihydroorotate dehydrogenase | Schistosoma mansoni | IC50 | 20.0000 | 2 | 2 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 0.0115 | 26 | 26 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 0.2042 | 4 | 5 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | Ki | 0.0120 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | EC50 | 0.0550 | 1 | 1 |